Article
HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions.
Nature genetics - 1 Nov 1999
de Wind N, Dekker M, Claij N, Jansen L, van Klink Y, Radman M, Riggins G, van der Valk M, van't Wout K, te Riele H
Abstract excerpt
Cancer predisposition in hereditary non-polyposis colon cancer (HNPCC) is caused by defects in DNA mismatch repair (MMR). Mismatch recognition is attributed to two heterodimeric protein complexes: MutSalpha (refs 2, 3, 4, 5), a dimer of MutS homologues MSH2 and MSH6; and MutSbeta (refs 2,7), a dimer of MSH2 and MSH3. These complexes have specific and redundant mismatch recognition capacity. Whereas MSH2...
Topics
- Alleles
- Animals
- Base Pair Mismatch
- Cell Death
- Colorectal Neoplasms, Hereditary Nonpolyposis
- DNA Repair
- DNA-Binding Proteins
- Female
- Gene Deletion
- Genetic Predisposition to Disease
- Incidence
- Male
- Methylnitronitrosoguanidine