Article
Risk of colorectal polyps and of malignancies in asymptomatic carriers of mutations in the main DNA mismatch repair genes.
Scandinavian journal of gastroenterology - 1 Jan 2018
Ponz de Leon Maurizio, Pedroni Monica, Pezzi Annalisa, Sulce Blerta, Roncucci Luca, Domati Federica, Rossi Giuseppina, Reggiani Bonetti Luca
Abstract excerpt
OBJECTIVE: Mutation carriers (Mut+) in DNA mismatch repair genes are predisposed to cancer of various organs and to adenomatous polyps; however, they may remain asymptomatic and cancer or polyp-free for several years. We purposed to analyse the clinical follow-up of individuals carrying constitutional mutations in the MLH1, MSH2 or MSH6 genes who were unaffected by benign polyps or malignant tumours at diagnosis....
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