Article
A lack of DNA mismatch repair on an athymic murine background predisposes to hematologic malignancy.
Cancer research - 1 Apr 2005
Campbell Marcia R, Nation Patrick N, Andrew Susan E
Abstract excerpt
Inheritance of a germline mutation in one of the DNA mismatch repair genes predisposes human individuals to hereditary nonpolyposis colorectal cancer, characterized by development of tumors predominantly in the colon, endometrium, and gastrointestinal tract. Mice heterozygous for a mismatch repair-null mutation generally do not have an increased risk of neoplasia. However, mice constitutively lacking mismatch...
Topics
- Animals
- Colon
- DNA Repair
- DNA-Binding Proteins
- Female
- Forkhead Transcription Factors
- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- Genetic Predisposition to Disease
- Immunohistochemistry
- Lymphoma, B-Cell
- Male
- Mice
- Mice, Knockout
- Mice, Nude
- Microsatellite Repeats
- MutS Homolog 2 Protein
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Proto-Oncogene Proteins