Quantitative measurements of the cooperativity in an EF-hand protein with sequential calcium binding.

doi:10.1002/pro.5560040602

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Article

Quantitative measurements of the cooperativity in an EF-hand protein with sequential calcium binding.

Protein science : a publication of the Protein Society - 1 Jun 1995

Linse S, Chazin W J

Abstract excerpt

Positive cooperativity, defined as an enhancement of the ligand affinity at one site as a consequence of binding the same type of ligand at another site, is a free energy coupling between binding sites. It can be present both in systems with sites having identical ligand affinities and in systems...

Topics

Allosteric Regulation
Cadmium
Calbindins
Calcium
Cations
Helix-Loop-Helix Motifs
Lanthanum
Magnetic Resonance Spectroscopy
Models, Chemical
Mutation
Recombinant Proteins
S100 Calcium Binding Protein G

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