Article
Quantitative measurements of the cooperativity in an EF-hand protein with sequential calcium binding.
Protein science : a publication of the Protein Society - 1 Jun 1995
Linse S, Chazin W J
Abstract excerpt
Positive cooperativity, defined as an enhancement of the ligand affinity at one site as a consequence of binding the same type of ligand at another site, is a free energy coupling between binding sites. It can be present both in systems with sites having identical ligand affinities and in systems where the binding sites have different affinities. When the sites have widely different affinities such that they are...
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