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Article

Comprehensive analysis of the roles of 'black' and 'gray' clusters in structure and function of rat β-parvalbumin.

Cell calcium - 1 Nov 2018

Permyakov Sergei E, Vologzhannikova Alisa A, Khorn Polina A, Shevelyova Marina P, Kazakov Alexei S, Emelyanenko Victor I, Denesyuk Alexander I, Denessiouk Konstantin, Uversky Vladimir N, Permyakov Eugene A

Abstract excerpt

Recently we found two highly conserved structural motifs in the proteins of the EF-hand calcium binding protein family. These motifs provide a supporting scaffold for the Ca2+ binding loops and contribute to the hydrophobic core of the EF-hand domain. Each structural motif forms a cluster of three amino acids called cluster I ('black' cluster) and cluster II ('grey' cluster). Cluster I is much more conserved and...

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PMID: 30176502
DOI: 10.1016/j.ceca.2018.08.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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