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Article

Solvation energetics and conformational change in EF-hand proteins.

Protein science : a publication of the Protein Society - 1 Feb 2001

Ababou A, Desjarlais J R

Abstract excerpt

Calmodulin and other members of the EF-hand protein family are known to undergo major changes in conformation upon binding Ca(2+). However, some EF-hand proteins, such as calbindin D9k, bind Ca(2+) without a significant change in conformation. Here, we show the importance of a precise balance of solvation energetics to conformational change, using mutational analysis of partially buried polar groups in the...

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Identifiers

PMID: 11266616
DOI: 10.1110/ps.33601
PMCID: PMC2373930

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