Article
Effects of various cytochrome P-450 inducers on testosterone metabolism and several monooxygenase activities in Sprague-Dawley (SpD), high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats.
Alcohol and alcoholism (Oxford, Oxfordshire) - 1 May 1995
Duffy O, Berthou F, Bardou L G, Ménez J F
Abstract excerpt
Hydroxylation of testosterone (TST) has been shown to be regio- and stereo-specific for a number of cytochrome P-450 isoenzymes. Three rat lines [Sprague-Dawley (SpD), high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS)] were tested for this enzymatic specificity after treatment with phenobarbital, clofibrate, 3-methylcholanthrene and pregnenolone-16 alpha-carbonitrile. These compounds are known to...
Topics
- Alcoholism
- Animals
- Cytochrome P-450 Enzyme System
- Enzyme Induction
- Hydroxylation
- Isoenzymes
- Male
- Oxygenases
- Phenotype
- Rats
- Rats, Sprague-Dawley