Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites.

doi:10.1021/bi00180a040

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Article

Structural determinants of cytochrome P450 2B1 specificity: evidence for five substrate recognition sites.

Biochemistry - 12 Apr 1994

He Y, Luo Z, Klekotka P A, Burnett V L, Halpert J R

Abstract excerpt

Twelve site-directed mutants of rat cytochrome P450 2B1 distributed over seven positions and four putative substrate recognition sites (SRS) were constructed and expressed in COS cells. Function was examined using androstenedione and testosterone as substrates. Substitutions at positions 303, 360...

Topics

Amino Acid Sequence
Animals
Aryl Hydrocarbon Hydroxylases
Base Sequence
Cells, Cultured
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
DNA Primers
Molecular Sequence Data
Mutation
Rats
Steroid Hydroxylases
Substrate Specificity

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Open in PubMed

Identifiers

PMID: 8155660
DOI: 10.1021/bi00180a040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8155660-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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