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Article

Ovariectomy modulates the response of some cytochrome P450 isozymes to lindane in the rat.

Toxicology letters - 15 Oct 2001

Oropeza-Hernández L F, Sierra-Santoyo A, Cebrián M E, Manno M, Albores A

Abstract excerpt

The effect of 0, 1, 5, 25 and 50 mg/kg body weight (b.w.) lindane, administered in corn oil by gavage, on cytochrome P450 (CYP) phenotype was investigated in the liver of ovariectomized (ovx), sham operated (sham-ope) and nonovariectomized (n/ovx) adult Wistar rats. Total hepatic microsomal CYP content and the O-dealkylation of 7-ethoxy- (EROD), 7-methoxy- (MROD), 7-pentoxy- (PROD) and 7-benzyloxy-resorufin...

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PMID: 11684361
DOI: 10.1016/s0378-4274(01)00383-6

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