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Article

Behavioral effects and pharmacokinetics of propofol in rats selected for differential ethanol sensitivity.

Alcoholism, clinical and experimental research - 1 Aug 1995

Liu Y, Fay T, Deitrich R A

Abstract excerpt

High- and low-alcohol sensitivity (HAS and LAS) rats have been selected for their differences in ethanol-induced sleep time. The rats also differ in sensitivity to pentobarbital, halothane, isoflurane, and enflurane. To determine if this sensitivity extended to propofol, the anesthetic requiremen...

Topics

Alcoholism
Animals
Female
Hypnotics and Sedatives
Male
Metabolic Clearance Rate
Phenotype
Propofol
Rats
Rats, Inbred Strains
Selection, Genetic
Sleep Stages

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Identifiers

PMID: 7485833
DOI: 10.1111/j.1530-0277.1995.tb00961.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7485833-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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