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Article

Cytochrome P450-mediated metabolism of haloperidol and reduced haloperidol to pyridinium metabolites.

Chemical research in toxicology - 1 Jul 2006

Avent Kathryn M, DeVoss J J, Gillam Elizabeth M J

Abstract excerpt

Haloperidol (HP) has been reported to undergo cytochrome P450 (P450)-mediated metabolism to potentially neurotoxic pyridinium metabolites; however, the chemical pathways and specific enzymes involved in these reactions remain to be identified. The aims of the current study were to (i) fully identify the cytochrome P450 enzymes capable of metabolizing HP to the pyridinium metabolite,...

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Identifiers

PMID: 16841959
DOI: 10.1021/tx0600090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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