Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats.

doi:10.1111/j.1530-0277.1992.tb01893.x

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Article

Differences in hepatic microsomal cytochrome P-450 isoenzyme induction by pyrazole, chronic ethanol, 3-methylcholanthrene, and phenobarbital in high alcohol sensitivity (HAS) and low alcohol sensitivity (LAS) rats.

Alcoholism, clinical and experimental research - 1 Oct 1992

Lucas D, Ménez J F, Berthou F, Cauvin J M, Deitrich R A

Abstract excerpt

High and low alcohol sensitivity (HAS and LAS) rats have been selected for their differences in ethanol-induced sleep time. Liver monooxygenase activities were studied in HAS and LAS rats before and after treatments with known inducers such as chronic ethanol, pyrazole, 3-methylcholanthrene (3-MC) and phenobarbital (PB) to determine whether the selection procedure also selected for differences in the cytochrome...

Topics

Alcoholism
Animals
Cytochrome P-450 Enzyme System
Enzyme Induction
Ethanol
Isoenzymes
Male
Methylcholanthrene
Microsomes, Liver
Phenobarbital

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Pyrazoles

Rats

Rats, Inbred Strains

Selection, Genetic

Species Specificity

Source

Open in PubMed

Identifiers

PMID: 1443430
DOI: 10.1111/j.1530-0277.1992.tb01893.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1443430-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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