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Article

Tryptophan metabolism in male Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats.

Alcohol and alcoholism (Oxford, Oxfordshire) - 1 Jan 2000

Bano S, Morgan C J, Badawy A A, Colombo G, Buckland P R, McGuffin P, Fadda F, Gessa G L

Abstract excerpt

Parameters of tryptophan (Trp) and related metabolism were compared in male Sardinian alcohol-preferring (sP) and -non-preferring (sNP) rats. Liver Trp pyrrolase activity was 38-58% higher in sP than in sNP rats, and this was associated with a greater expression of the enzyme mRNA as measured by...

Topics

Alcoholism
Animals
Brain
Gene Expression Regulation, Enzymologic
Genotype
Hydroxyindoleacetic Acid
Liver
Male
RNA, Messenger
Rats
Rats, Inbred Strains
Serotonin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Tryptophan

Tryptophan Oxygenase

Source

Identifiers

PMID: 9632047
DOI: 10.1093/oxfordjournals.alcalc.a008385

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9632047-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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