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Article

Occurrence of mutations in the epidermal growth factor receptor gene in X-ray-induced rat lung tumors.

Cancer science - 1 Feb 2008

Kitahashi Tsukasa, Takahashi Mami, Yamada Yutaka, Oghiso Yoichi, Yokohira Masanao, Imaida Katsumi, Tsutsumi Masahiro, Takasuka Nobuo, Sugimura Takashi, Wakabayashi Keiji

Abstract excerpt

Epidermal growth factor receptor (EGFR) gene alterations have been found in human lung cancers. However, there is no information on the factors inducing EGFR mutations. In rodents, K-ras mutations are frequently found in many lung carcinogenesis models, but hitherto, Egfr mutations have not been reported. Their presence was therefore investigated in representative lung carcinogenesis models with...

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Identifiers

PMID: 18271921
DOI: 10.1111/j.1349-7006.2008.00680.x
PMCID: PMC11159033

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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