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Article

Mutation of a highly conserved base in the yeast mitochondrial 21S rRNA restricts ribosomal frameshifting.

Molecular & general genetics : MGG - 28 Jul 1995

Weiss-Brummer B, Zollner A, Haid A, Thompson S

Abstract excerpt

A mutation shown to cause resistance to chloramphenicol in Saccharomyces cerevisiae was mapped to the central loop in domain V of the yeast mitochondrial 21S rRNA. The mutant 21S rRNA has a base pair exchange from U2677 (corresponding to U2504 in Escherichia coli) to C2677, which significantly reduces rightward frameshifting at a UU UUU UCC A site in a +1 U mutant. There is evidence to suggest that this reduction...

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Identifiers

PMID: 7544431
DOI: 10.1007/BF02190802
PMCID: PMC7087996

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