Article
Mutation of a highly conserved base in the yeast mitochondrial 21S rRNA restricts ribosomal frameshifting.
Molecular & general genetics : MGG - 28 Jul 1995
Weiss-Brummer B, Zollner A, Haid A, Thompson S
Abstract excerpt
A mutation shown to cause resistance to chloramphenicol in Saccharomyces cerevisiae was mapped to the central loop in domain V of the yeast mitochondrial 21S rRNA. The mutant 21S rRNA has a base pair exchange from U2677 (corresponding to U2504 in Escherichia coli) to C2677, which significantly re...
Topics
- Amino Acid Sequence
- Base Sequence
- Chloramphenicol Resistance
- Codon, Nonsense
- Conserved Sequence
- Electron Transport Complex IV
- Frameshift Mutation
- Genes, Reporter
- Mitochondria
- Molecular Sequence Data
- Nucleic Acid Conformation
- Phenotype
- Point Mutation
- Protein Biosynthesis
- RNA
- RNA, Fungal
- RNA, Mitochondrial
- RNA, Ribosomal