Article
Mitochondrial deafness alleles confer misreading of the genetic code.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2008
Hobbie Sven N, Bruell Christian M, Akshay Subramanian, Kalapala Sarath K, Shcherbakov Dmitry, Böttger Erik C
Abstract excerpt
Despite the fact that important genetic diseases are caused by mutant mitochondrial ribosomes, the molecular mechanisms by which such ribosomes result in a clinical phenotype remain largely unknown. The absence of experimental models for mitochondrial diseases has also prevented the rational search for therapeutic interventions. Here, we report on the construction of bacterial hybrid ribosomes that contain...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.