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Article

Nucleotide modifications in three functionally important regions of the Saccharomyces cerevisiae ribosome affect translation accuracy.

Nucleic acids research - 1 Dec 2009

Baudin-Baillieu Agnès, Fabret Céline, Liang Xue-Hai, Piekna-Przybylska Dorota, Fournier Maurille J, Rousset Jean-Pierre

Abstract excerpt

Important regions of rRNA are rich in nucleotide modifications that can have strong effects on ribosome biogenesis and translation efficiency. Here, we examine the influence of pseudouridylation and 2'-O-methylation on translation accuracy in yeast, by deleting the corresponding guide snoRNAs. The regions analyzed were: the decoding centre (eight modifications), and two intersubunit bridge domains-the A-site...

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Identifiers

PMID: 19820108
DOI: 10.1093/nar/gkp816
PMCID: PMC2794176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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