Article
Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1995
Frenette P S, Johnson R C, Hynes R O, Wagner D D
Abstract excerpt
P-selectin, found in storage granules of platelets and endothelial cells, can be rapidly expressed upon stimulation. Mice lacking this membrane receptor exhibit a severe impairment of leukocyte rolling. We observed that, in addition to leukocytes, platelets were rolling in mesenteric venules of wild-type mice. To investigate the role of P-selectin in this process, resting or activated platelets from wild-type or...
Topics
- Animals
- Blood Platelets
- Calcimycin
- Cell Movement
- Endothelium, Vascular
- Leukocytes
- Male
- Mice
- Mice, Inbred C57BL
- Microscopy, Phase-Contrast
- Mutation