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Article

Cytoskeletal regulation of CD44 membrane organization and interactions with E-selectin.

The Journal of biological chemistry - 19 Dec 2014

Wang Ying, Yago Tadayuki, Zhang Nan, Abdisalaam Salim, Alexandrakis George, Rodgers William, McEver Rodger P

Abstract excerpt

Interactions of CD44 on neutrophils with E-selectin on activated endothelial cells mediate rolling under flow, a prerequisite for neutrophil arrest and migration into perivascular tissues. How CD44 functions as a rolling ligand despite its weak affinity for E-selectin is unknown. We examined the nanometer scale organization of CD44 on intact cells. CD44 on leukocytes and transfected K562 cells was cross-linked...

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Identifiers

PMID: 25359776
DOI: 10.1074/jbc.M114.600767
PMCID: PMC4271205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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