Article
P-selectin must extend a sufficient length from the plasma membrane to mediate rolling of neutrophils.
The Journal of cell biology - 1 Dec 1995
Patel K D, Nollert M U, McEver R P
Abstract excerpt
Under physiological shear stress, neutrophils roll on P-selectin on activated endothelial cells or platelets through interactions with P-selectin glycoprotein ligand-1 (PSGL-1). Both P-selectin and PSGL-1 are extended molecules. Human P-selectin contains an NH2-terminal lectin domain, an EGF domain, nine consensus repeats (CRs), a transmembrane domain, and a cytoplasmic tail. To determine whether the length of...
Topics
- Animals
- CHO Cells
- Cell Adhesion
- Cell Membrane
- Cell Movement
- Cricetinae
- Glycoproteins
- Humans
- Mutation
- Neutrophils
- P-Selectin
- Polysaccharides