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Article

A new role in hemostasis for the adhesion receptor P-selectin.

Trends in molecular medicine - 1 Apr 2004

Cambien Beatrice, Wagner Denisa D

Abstract excerpt

The adhesion receptor P-selectin has long been known to support leukocyte rolling and emigration at sites of inflammation. Recently, P-selectin was also revealed to be a key molecule in hemostasis and thrombosis, mediating platelet rolling, generating procoagulant microparticles containing active tissue factor and enhancing fibrin deposition. Elevated levels of plasma P-selectin are indicative of thrombotic...

Topics

Animals
Blood Coagulation Disorders
Cardiovascular Diseases
Cell Adhesion
Fibrin
Humans
Inflammation
Leukocytes
Membrane Glycoproteins
Mice
Models, Biological
P-Selectin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protein Binding

Protein Structure, Tertiary

Thromboplastin

Thrombosis

Source

Identifiers

PMID: 15059609
DOI: 10.1016/j.molmed.2004.02.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-15059609-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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