Article
A new role in hemostasis for the adhesion receptor P-selectin.
Trends in molecular medicine - 1 Apr 2004
Cambien Beatrice, Wagner Denisa D
Abstract excerpt
The adhesion receptor P-selectin has long been known to support leukocyte rolling and emigration at sites of inflammation. Recently, P-selectin was also revealed to be a key molecule in hemostasis and thrombosis, mediating platelet rolling, generating procoagulant microparticles containing active tissue factor and enhancing fibrin deposition. Elevated levels of plasma P-selectin are indicative of thrombotic...
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