Renal protective effect of TCV-116 in stroke-prone spontaneously hypertensive rats.

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Article

Renal protective effect of TCV-116 in stroke-prone spontaneously hypertensive rats.

Blood pressure. Supplement - 1 Jan 1994

Kim S, Ohta K, Hamaguchi A, Omura T, Yukimura T, Miura K, Inada Y, Wada T, Ishimura Y, Chatani F

Abstract excerpt

We examined the effects of TCV-116, a non-peptide selective AT1 receptor antagonist, on cellular phenotype and on the expression of the transforming growth factor-beta 1 (TGF-beta 1) and extracellular matrix genes in the kidneys of stroke-prone spontaneously hypertensive rats (SHRSP). SHRSP were...

Topics

Albuminuria
Angiotensin II
Angiotensin Receptor Antagonists
Animals
Antihypertensive Agents
Benzimidazoles
Biphenyl Compounds
Cerebrovascular Disorders
Extracellular Matrix
Gene Expression
Hypertension, Renal
Kidney
Kidney Glomerulus
Male
Phenotype
Prodrugs
RNA, Messenger
Rats

Source

Open in PubMed

Identifiers

PMID: 7889201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7889201-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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