Article
Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups.
Antiviral research - 1 Mar 1995
Buckheit R W, Fliakas-Boltz V, Decker W D, Roberson J L, Stup T L, Pyle C A, White E L, McMahon J B, Currens M J, Boyd M R
Abstract excerpt
We have biologically and biochemically evaluated a structurally diverse group of HIV-1-specific reverse transcriptase (RT) inhibitors and determined that the members of this class share many common properties. These include reproducible and selective antiviral activity against a panel of biologic...
Topics
- Antiviral Agents
- Cell Line
- Drug Evaluation
- Drug Interactions
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Phenotype
- Reproducibility of Results
- Reverse Transcriptase Inhibitors
- Zidovudine