Article
Comparative anti-HIV evaluation of diverse HIV-1-specific reverse transcriptase inhibitor-resistant virus isolates demonstrates the existence of distinct phenotypic subgroups.
Antiviral research - 1 Mar 1995
Buckheit R W, Fliakas-Boltz V, Decker W D, Roberson J L, Stup T L, Pyle C A, White E L, McMahon J B, Currens M J, Boyd M R
Abstract excerpt
We have biologically and biochemically evaluated a structurally diverse group of HIV-1-specific reverse transcriptase (RT) inhibitors and determined that the members of this class share many common properties. These include reproducible and selective antiviral activity against a panel of biologically distinct laboratory and clinical strains of HIV-1, activity against HIV-1 in a wide variety of cultured and fresh...
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