Article
HIV-1-specific reverse transcriptase inhibitors show differential activity against HIV-1 mutant strains containing different amino acid substitutions in the reverse transcriptase.
Virology - 1 Jan 1993
Balzarini J, Karlsson A, Pérez-Pérez M J, Vrang L, Walbers J, Zhang H, Oberg B, Vandamme A M, Camarasa M J, De Clercq E
Abstract excerpt
Serial passage of HIV-1 in CEM or MT-4 cell cultures in the presence of different HIV-1-specific reverse transcriptase (RT) inhibitors yielded mutant viruses which were resistant (i.e., 200- to 1000-fold less sensitive) to the homologous compounds. The RT of these mutant HIV-1 strains showed different amino acid substitutions depending on the class of the HIV-1-specific RT inhibitors. The following amino acid...
Topics
- Amino Acid Sequence
- Base Sequence
- Genes, pol
- HIV Reverse Transcriptase
- HIV-1
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- RNA-Directed DNA Polymerase
- Reverse Transcriptase Inhibitors