Article
Susceptibilities of human immunodeficiency virus type 1 enzyme and viral variants expressing multiple resistance-engendering amino acid substitutions to reserve transcriptase inhibitors.
Antimicrobial agents and chemotherapy - 1 Jun 1994
Byrnes V W, Emini E A, Schleif W A, Condra J H, Schneider C L, Long W J, Wolfgang J A, Graham D J, Gotlib L, Schlabach A J
Abstract excerpt
To evaluate the potential that multiply resistant human immunodeficiency virus type 1 variants may arise during combination nucleoside and nonnucleoside reverse transcriptase inhibitor therapy, we constructed a series of mutant reverse transcriptase enzymes and viruses that coexpressed various combinations of resistance-associated amino acid substitutions. Substitutions at residues 100 (Leu-->Ile) and 181...
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