Different properties of wild type and drug-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase in vitro.

doi:10.1111/j.1348-0421.1996.tb01079.x

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Article

Different properties of wild type and drug-resistant mutants of human immunodeficiency virus type 1 reverse transcriptase in vitro.

Microbiology and immunology - 1 Jan 1996

Ijichi K, Fujiwara M, Shigeta S, Konno K, Yokota T, Baba M

Abstract excerpt

Drug-resistant mutants of human immunodeficiency virus type 1 (HIV-1) emerge during treatment with various reverse transcriptase (RT) inhibitors in vitro and in vivo. However, the virological nature and pathogenic importance of these mutants have not been fully elucidated. In this study, we have...

Topics

Antiviral Agents
Cells, Cultured
DNA, Viral
Drug Resistance, Microbial
HIV Infections
HIV-1
Humans
Mutation
Proviruses
RNA-Directed DNA Polymerase
Uracil
Virus Replication
Zidovudine

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