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Article

Comprehensive mutant enzyme and viral variant assessment of human immunodeficiency virus type 1 reverse transcriptase resistance to nonnucleoside inhibitors.

Antimicrobial agents and chemotherapy - 1 Aug 1993

Byrnes V W, Sardana V V, Schleif W A, Condra J H, Waterbury J A, Wolfgang J A, Long W J, Schneider C L, Schlabach A J, Wolanski B S

Abstract excerpt

The nonnucleoside reverse transcriptase (RT) inhibitors comprise a class of structurally diverse compounds that are functionally related and specific for the human immunodeficiency virus type 1 RT. Viral variants resistant to these compounds arise readily in cell culture and in treated, infected...

Topics

Acquired Immunodeficiency Syndrome
Antiviral Agents
Benzoxazoles
DNA, Viral
Genetic Variation
HIV Reverse Transcriptase
HIV-1
Humans
Mutation
Nucleosides
Pyridones

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA-Directed DNA Polymerase

Reverse Transcriptase Inhibitors

Structure-Activity Relationship

Source

Open in PubMed Open full text

Identifiers

PMID: 7692811
DOI: 10.1128/AAC.37.8.1576
PMCID: PMC188022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7692811-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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