Article
The genetic and functional basis of HIV-1 resistance to nonnucleoside reverse transcriptase inhibitors.
Archives of virology. Supplementum - 1 Jan 1994
Emini E A, Byrnes V W, Condra J H, Schleif W A, Sardana V V
Abstract excerpt
The nonnucleoside reverse transcriptase (RT) inhibitors are structurally diverse compounds that are specific inhibitors of the human immunodeficiency virus type 1 RT enzyme. The compounds are largely functionally identical and bind to a common site in the enzyme. HIV-1 variants that exhibit reduced susceptibility to these inhibitors have been derived in cell culture and, more recently, from HIV-1-infected...
Topics
- Antiviral Agents
- Benzodiazepines
- Benzoxazoles
- Clinical Trials as Topic
- Drug Resistance, Microbial
- Genetic Variation
- HIV Infections
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Imidazoles