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Article

Effect of substitution for arginine residues near position 146 of the A subunit of Escherichia coli heat-labile enterotoxin on the holotoxin assembly.

Microbiology and immunology - 1 Jan 1995

Okamoto K, Takatori R, Okamoto K

Abstract excerpt

Escherichia coli heat-labile enterotoxin (LT) is a holotoxin which consists of one A and five B subunits. Although B subunit monomers released into periplasm can associate into pentameric structures in the absence of the A subunit, the A subunit accelerates the assembly. To express the function, A subunit constructs the proper spatial structure. However, the regions involved in the construction are unknown. To...

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PMID: 7541507
DOI: 10.1111/j.1348-0421.1995.tb02188.x

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