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Article

Involvement of the COOH-terminal pro-sequence of Serratia marcescens serine protease in the folding of the mature enzyme.

The Journal of biological chemistry - 30 Dec 1994

Ohnishi Y, Nishiyama M, Horinouchi S, Beppu T

Abstract excerpt

The serine protease (SSP) from a Gram-negative organism, Serratia marcescens, is excreted even from Escherichia coli. The protease is synthesized as a 1045-amino-acid precursor (preproSSP) composed of three functional portions, a typical NH2-terminal signal peptide of 27 amino acids, the mature protease part of 618 amino acids, and a large COOH-terminal part of 400 amino acids. After the mature part (Ala28 to...

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PMID: 7806503

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