Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[An insertion mutant of LeuRS with 116 amino acid residues has full activity].

Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica - 1 Mar 2003

Huang Ying, Ling Chen, Li Tong, Tong Geng-Lei, Wang En-Duo

Abstract excerpt

Escherichia coli leucyl-tRNA synthetase (LeuRS) belongs to class I aminoacyl-tRNA synthetases. It consists of 860 amino acid residues and catalyzes the leucylation of tRNA(Leu). An insertion of its 253-368 peptide fragment between 368 to 369 in CP1 domain of this enzyme was shown to maintain the activity of the enzyme, and the insertion mutant was named as LeuRS-C. Because the insertion mutant of LeuRS was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Circular Dichroism
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Enzyme Stability

Share to Leucine

Share to Mutagenesis, Insertional

Share to Peptide Fragments

Share to Plasmids

Share to Temperature

Source

Identifiers

PMID: 12621546

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

[An insertion mutant of LeuRS with 116 amino acid residues has full activity].PMID 12621546Read ↗

Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase.Semantic proximity Read ↗

Two tyrosine residues outside the editing active site in Giardia lamblia leucyl-tRNA synthetase are essential for the post-transfer editing.Semantic proximity Read ↗

tRNA-dependent pre-transfer editing by prokaryotic leucyl-tRNA synthetase.Semantic proximity Read ↗

Leucine-specific domain modulates the aminoacylation and proofreading functional cycle of bacterial leucyl-tRNA synthetase.Semantic proximity Read ↗

A Flexible peptide tether controls accessibility of a unique C-terminal RNA-binding domain in leucyl-tRNA synthetases.Semantic proximity Read ↗

The Yin and Yang of tRNA: proper binding of acceptor end determines the catalytic balance of editing and aminoacylation.Semantic proximity Read ↗

Arginyl-tRNA synthetase with signature sequence KMSK from Bacillus stearothermophilus.Semantic proximity Read ↗

An inserted region of leucyl-tRNA synthetase plays a critical role in group I intron splicing.Semantic proximity Read ↗

Modulation of Aminoacylation and Editing Properties of Leucyl-tRNA Synthetase by a Conserved Structural Module.Semantic proximity Read ↗

Glutaminyl-tRNA synthetase.Semantic proximity Read ↗

The effects of a unique D-loop structure of a minor tRNA(UUALeu) from Streptomyces on its structural stability and amino acid accepting activity.Semantic proximity Read ↗

Single amino acid changes in AspRS reveal alternative routes for expanding its tRNA repertoire in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.