Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain.

doi:10.1074/jbc.270.26.15463

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Article

Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain.

The Journal of biological chemistry - 30 Jun 1995

Kawamura A, Su M S

Abstract excerpt

Calcineurin is a calcium-dependent protein phosphatase that plays a pivotal role in antigen-stimulated T cell activation. The complexes formed between the immunosuppressants cyclosporin A and FK506 and their respective intracellular binding proteins (immunophilins) block T cell activation by bind...

Topics

Amino Acid Sequence
Binding Sites
Calcineurin
Calmodulin-Binding Proteins
Carrier Proteins
DNA-Binding Proteins
Heat-Shock Proteins
Humans
Molecular Sequence Data
Mutation
NF-kappa B
Phosphoprotein Phosphatases
Phosphoric Monoester Hydrolases
Tacrolimus
Tacrolimus Binding Proteins
Transcriptional Activation

Source

Open in PubMed

Identifiers

PMID: 7541044
DOI: 10.1074/jbc.270.26.15463

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7541044-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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