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Article

Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain.

The Journal of biological chemistry - 30 Jun 1995

Kawamura A, Su M S

Abstract excerpt

Calcineurin is a calcium-dependent protein phosphatase that plays a pivotal role in antigen-stimulated T cell activation. The complexes formed between the immunosuppressants cyclosporin A and FK506 and their respective intracellular binding proteins (immunophilins) block T cell activation by binding to calcineurin. Recent studies have shown that the immunophilin-immunosuppressant complexes interact with the latch...

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Source

Identifiers

PMID: 7541044
DOI: 10.1074/jbc.270.26.15463

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain.PMID 7541044Read ↗

Regulation of calcineurin phosphatase activity and interaction with the FK-506.FK-506 binding protein complex.Semantic proximity Read ↗

Targets of immunophilin‐immunosuppressant complexes are distinct highly conserved regions of calcineurin A.Semantic proximity Read ↗

The regulatory domains of CNA have different effects on the inhibition of CN activity by FK506 and CsA.Semantic proximity Read ↗

Different roles of Loop 7 in inhibition of calcineurin.Semantic proximity Read ↗

A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.Semantic proximity Read ↗

Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.Semantic proximity Read ↗

FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.Semantic proximity Read ↗

Leveraging Fungal Calcineurin-Inhibitor Structures, Biophysics and Dynamics to Design Selective and Non-Immunosuppressive FK506 AnalogsSemantic proximity Read ↗

A role of calcineurin in coreceptor regulation during differentiation of Cd4+Cd8+ T cells.Semantic proximity Read ↗

High activity of the calcineurin A subunit with a V314 deletion.Semantic proximity Read ↗

TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and FunctionSemantic proximity Read ↗

Calcineurin mediates inhibition by FK506 and cyclosporin of recovery from alpha-factor arrest in yeast.Semantic proximity Read ↗

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