Article
A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants.
Molecular cell - 13 Mar 2009
Rodríguez Antonio, Roy Jagoree, Martínez-Martínez Sara, López-Maderuelo María Dolores, Niño-Moreno Perla, Ortí Leticia, Pantoja-Uceda David, Pineda-Lucena Antonio, Cyert Martha S, Redondo Juan Miguel
Abstract excerpt
The phosphatase calcineurin, a target of the immunosuppressants cyclosporin A and FK506, dephosphorylates NFAT transcription factors to promote immune activation and development of the vascular and nervous systems. NFAT interacts with calcineurin through distinct binding motifs: the PxIxIT and LxVP sites. Although many calcineurin substrates contain PxIxIT motifs, the generality of LxVP-mediated interactions is...
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