Article
FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
Biochemical and biophysical research communications - 21 May 2020
Juvvadi Praveen R, Bobay Benjamin G, Gobeil Sophie M C, Cole D Christopher, Venters Ronald A, Heitman Joseph, Spicer Leonard D, Steinbach William J
Abstract excerpt
The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing organ transplant rejection. Our recent characterization of crystal structures of FKBP12 proteins in pathogenic fungi revealed the involvement of the 80's loop residue (Pro90) in the active...
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