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Article

Different roles of Loop 7 in inhibition of calcineurin.

Biochemical and biophysical research communications - 19 Oct 2007

Wang Hailong, Yao Siyan, Lin Weilin, Du Yanwei, Xiang Benqiong, He Shuai, Huang Chao, Wei Qun

Abstract excerpt

Calcineurin (CN) is the receptor for two immunophilin-immunosuppressant complexes, Cyp-CsA and FKBP-FK506. It is a heterodimer composed of a catalytic subunit (CNA) and a regulatory subunit (CNB). It is also inhibited by its own auto-inhibitory domain (AID). Loop 7 is a beta-hairpin within CNA that makes close contact with bound immunophilin-immunosuppressant complexes and with the AID. To investigate the role of...

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Identifiers

PMID: 17707777
DOI: 10.1016/j.bbrc.2007.07.195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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