Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.

doi:10.1038/371355a0

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Article

Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.

Nature - 22 Sept 1994

Bram R J, Crabtree G R

Abstract excerpt

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin, cyclosporin A binds and inactivates the key signalling intermediate calcineurin. To identify potential cellular homologues...

Topics

Adaptor Proteins, Signal Transducing
Amino Acid Isomerases
Amino Acid Sequence
Base Sequence
Calcium
Carrier Proteins
Cell Line
Cloning, Molecular
Cyclophilins
Cyclosporine
DNA
DNA-Binding Proteins
Humans
Lymphocyte Activation
Molecular Sequence Data
Mutation
NFATC Transcription Factors
Nuclear Proteins

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