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Article

Calcium signalling in T cells stimulated by a cyclophilin B-binding protein.

Nature - 22 Sept 1994

Bram R J, Crabtree G R

Abstract excerpt

The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin, cyclosporin A binds and inactivates the key signalling intermediate calcineurin. To identify potential cellular homologues of cyclosporin A that might regulate calcium signalling, we have cloned human genes encoding cyclophilin...

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PMID: 7522304
DOI: 10.1038/371355a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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