Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides.

Biochemical and biophysical research communications - 13 Jun 2003

Cai Jian-Ping, Ishibashi Toru, Takagi Yasumitsu, Hayakawa Hiroshi, Sekiguchi Mutsuo

Abstract excerpt

MutT-related proteins degrade 8-oxo-7,8-dihydrodeoxyguanosine triphosphate (8-oxo-dGTP), a mutagenic substrate for DNA synthesis, in the nucleotide pool, thereby preventing DNA replication errors. During a search of GenBank EST database, we found a new member of MutT-related protein, MTH2, which possesses the 23-amino acid MutT module. The cloned mouse MTH2 (mMTH2) cDNA was expressed in Escherichia coli mutT(-)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cloning, Molecular
Share to Deoxyguanine Nucleotides

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Escherichia coli

Share to Escherichia coli Proteins

Share to Phosphoric Diester Hydrolases

Share to Phosphoric Monoester Hydrolases

Share to Pyrophosphatases

Share to Sequence Alignment

Source

Identifiers

PMID: 12767940
DOI: 10.1016/s0006-291x(03)00864-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse MTH2 protein which prevents mutations caused by 8-oxoguanine nucleotides.PMID 12767940Read ↗

A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides.Semantic proximity Read ↗

Molecular genetics and structural biology of human MutT homolog, MTH1.Semantic proximity Read ↗

Bacterial DNA repair genes and their eukaryotic homologues: 2. Role of bacterial mutator gene homologues in human disease. Overview of nucleotide pool sanitization and mismatch repair systems.Semantic proximity Read ↗

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis.Semantic proximity Read ↗

Gene structure of human and mouse methylenetetrahydrofolate reductase (MTHFR)Semantic proximity Read ↗

A comparative study of the biochemical properties of human and mouse recombinant O6-methylguanine-DNA methyltransferases.Semantic proximity Read ↗

Biochemical properties of MutT2 proteins from Mycobacterium tuberculosis and M. smegmatis and their contrasting antimutator roles in Escherichia coli.Semantic proximity Read ↗

Mycobacterium tuberculosis MutT1 (Rv2985) and ADPRase (Rv1700) proteins constitute a two-stage mechanism of 8-oxo-dGTP and 8-oxo-GTP detoxification and adenosine to cytidine mutation avoidance.Semantic proximity Read ↗

Premature aging is associated with higher levels of 8-oxoguanine and increased DNA damage in the Polg mutator mouse.Semantic proximity Read ↗

NDX-1 protein hydrolyzes 8-oxo-7, 8-dihydrodeoxyguanosine-5'-diphosphate to sanitize oxidized nucleotides and prevent oxidative stress in Caenorhabditis elegans.Semantic proximity Read ↗

Counteraction by MutT protein of transcriptional errors caused by oxidative damage.Semantic proximity Read ↗

A novel Nudix hydrolase for oxidized purine nucleoside triphosphates encoded by ORFYLR151c (PCD1 gene) in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.