Article
Dibasic protein kinase A sites regulate bursting rate and nucleotide sensitivity of the cystic fibrosis transmembrane conductance regulator chloride channel.
The Journal of physiology - 15 Apr 1998
Mathews C J, Tabcharani J A, Chang X B, Jensen T J, Riordan J R, Hanrahan J W
Abstract excerpt
1. The relationship between phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel and its gating by nucleotides was examined using the patch clamp technique by comparing strongly phosphorylated wild-type (WT) channels with weakly phosphorylated mutant...
Topics
- Adenosine Triphosphate
- Animals
- CHO Cells
- Chloride Channels
- Cricetinae
- Cyclic AMP-Dependent Protein Kinases
- Cystic Fibrosis Transmembrane Conductance Regulator
- Ion Channel Gating
- Kinetics
- Mutation
- Nucleotides
- Phosphorylation