Article
The two nucleotide-binding domains of cystic fibrosis transmembrane conductance regulator (CFTR) have distinct functions in controlling channel activity.
The Journal of biological chemistry - 27 Jan 1995
Carson M R, Travis S M, Welsh M J
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel contains two cytoplasmic nucleotide-binding domains (NBDs). After phosphorylation of the R domain, ATP interacts with the NBDs to regulate channel activity. To learn how the NBDs regulate channel function, we used the patc...
Topics
- 3T3 Cells
- Adenosine Triphosphate
- Adenylyl Imidodiphosphate
- Amino Acid Sequence
- Animals
- Azides
- Binding Sites
- Chloride Channels
- Conserved Sequence
- Cyclic AMP-Dependent Protein Kinases
- Cystic Fibrosis Transmembrane Conductance Regulator
- Genetic Variation
- HeLa Cells
- Humans
- Ion Channel Gating
- Lysine
- Membrane Potentials
- Membrane Proteins