Article
Phosphatase inhibitors activate normal and defective CFTR chloride channels.
Proceedings of the National Academy of Sciences of the United States of America - 13 Sept 1994
Becq F, Jensen T J, Chang X B, Savoia A, Rommens J M, Tsui L C, Buchwald M, Riordan J R, Hanrahan J W
Abstract excerpt
The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is regulated by phosphorylation and dephosphorylation at multiple sites. Although activation by protein kinases has been studied in some detail, the dephosphorylation step has received little attention. This report examines the mechanisms responsible for the dephosphorylation and spontaneous deactivation ("rundown") of CFTR chloride...
Topics
- 1-Methyl-3-isobutylxanthine
- Animals
- CHO Cells
- Chloride Channels
- Cricetinae
- Cystic Fibrosis Transmembrane Conductance Regulator
- Humans
- In Vitro Techniques
- Membrane Proteins
- Mutation