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Article

Acquired ABC-transporter overexpression in cancer cells: transcriptional induction or Darwinian selection?

8 Jul 2021

Abstract excerpt

Acquired multidrug resistance (MDR) in tumor diseases has repeatedly been associated with overexpression of ATP-binding cassette transporters (ABC-transporters) such as P-glycoprotein. Both in vitro and in vivo data suggest that these efflux transporters can cause MDR, albeit its actual relevance for clinical chemotherapy unresponsiveness remains uncertain. The overexpression can experimentally be achieved by...

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PMID: 34236499
DOI: 10.1007/s00210-021-02112-3

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