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Article

Differential effects of mitomycin C and doxorubicin on P-glycoprotein expression

24 Apr 2001

Abstract excerpt

Previous studies have demonstrated that mitomycin C (MMC) and other DNA cross-linking agents can suppress MDR1 (multidrug resistance 1) gene expression and subsequent functional P-glycoprotein (Pgp) expression, whereas doxorubicin and other anthracyclines increase MDR1 gene expression. In the present study, with stably transfected Madin-Darby canine kidney C7 epithelial cells expressing a human Pgp tagged with...

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PMID: 11311122
DOI: 10.1042/bj3550617

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