Isolation and expression of a complementary DNA that confers multidrug resistance.

doi:10.1038/323728a0

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Article

Isolation and expression of a complementary DNA that confers multidrug resistance.

Nature - 1 Jan 2000

Gros P, Ben Neriah Y B, Croop J M, Housman D E

Abstract excerpt

The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high l...

Topics

Animals
Base Sequence
Cell Line
Cricetinae
DNA
DNA Restriction Enzymes
Drug Resistance
Gene Expression Regulation
Globins
Phenotype
RNA, Messenger
Transfection

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