Article
Isolation and expression of a complementary DNA that confers multidrug resistance.
Nature - 1 Jan 2000
Gros P, Ben Neriah Y B, Croop J M, Housman D E
Abstract excerpt
The emergence and outgrowth of a population of tumour cells resistant to multiple drugs is a major problem in the chemotherapeutic treatment of cancer. We have used highly drug-resistant cell lines developed in vitro to study the molecular basis of multidrug resistance. In these cell lines high levels of resistance are frequently associated with amplification and overexpression of a small group of genes termed...
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