A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance.

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Article

A mutation hot spot in the Bcrp1 (Abcg2) multidrug transporter in mouse cell lines selected for Doxorubicin resistance.

Cancer research - 15 Apr 2002

Allen John D, Jackson Sonja C, Schinkel Alfred H

Abstract excerpt

The recent identification of mutations at arginine 482 (R482) in human Breast Cancer Resistance Protein (BCRP) in two drug-selected cell lines largely explains some discrepancies observed in the cross-resistance profiles of human cell lines overexpressing this multidrug transporter. We find that each of three mouse cell lines independently selected for resistance to the anthracycline doxorubicin also acquired...

Topics

ATP Binding Cassette Transporter, Subfamily G, Member 2
ATP-Binding Cassette Transporters
Acridines
Animals
Antineoplastic Agents
Cell Line
Doxorubicin
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Fibroblasts
Isoquinolines
Mice
Mutation
Neoplasm Proteins
RNA, Messenger
Substrate Specificity
Tetrahydroisoquinolines

Source

Open in PubMed

Identifiers

PMID: 11956086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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