Article
The presence of p53 mutations in human osteosarcomas correlates with high levels of genomic instability.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2003
Overholtzer Michael, Rao Pulivarthi H, Favis Reyna, Lu Xin-Yan, Elowitz Michael B, Barany Francis, Ladanyi Marc, Gorlick Richard, Levine Arnold J
Abstract excerpt
The p53 gene is a critical tumor suppressor that is inactivated in a majority of cancers. The central role of p53 in response to stresses such as DNA damage, hypoxia, and oncogene activation underlies this high frequency of negative selection during tumorigenic transformation. Mutations in p53 disrupt checkpoint responses to DNA damage and result in the potential for destabilization of the genome. Consistent with...
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