Article
BRCA2 and p53 mutations in primary breast cancer in relation to genetic instability.
Cancer research - 1 Mar 1998
Gretarsdottir S, Thorlacius S, Valgardsdottir R, Gudlaugsdottir S, Sigurdsson S, Steinarsdottir M, Jonasson J G, Anamthawat-Jonsson K, Eyfjörd J E
Abstract excerpt
The products of the BRCA breast cancer susceptibility genes have been implicated in cell cycle control and DNA repair. It has been suggested that mutations in the p53 gene are a necessary step in tumorigenesis in BRCA tumors. We tested samples from 402 breast cancer patients for germ-line BRCA2 a...
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