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Article

Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene.

The Journal of clinical endocrinology and metabolism - 1 Jan 1995

Blakemore A I, Watson P F, Weetman A P, Duff G W

Abstract excerpt

The proinflammatory cytokine, interleukin-1 (IL-1), has been implicated in the pathogenesis of several autoimmune and inflammatory diseases. One of its natural inhibitors, IL-1 receptor antagonist, is a potent antiinflammatory agent. We have previously described genetic associations between an allele of the IL-1 receptor antagonist gene (IL1RN*2) and several autoimmune and inflammatory diseases. In the present...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 7530255
DOI: 10.1210/jcem.80.1.7530255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene.PMID 7530255Read ↗

Lack of association of Graves' disease with the A2 allele of the interleukin-1 receptor antagonist gene in a white European population.Semantic proximity Read ↗

Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist.Semantic proximity Read ↗

Interleukin-1-beta gene, but not the interleukin-1 receptor antagonist gene, is associated with Graves' disease.Semantic proximity Read ↗

Genetic Associations of Interleukin-related Genes with Graves' Ophthalmopathy: a Systematic Review and Meta-analysis.Semantic proximity Read ↗

Polymorphisms in IL-1beta and IL-1 receptor antagonist genes are associated with myasthenia gravis.Semantic proximity Read ↗

Genetic susceptibility to Graves' ophthalmopathy: The role of polymorphisms in anti-inflammatory cytokine genes.Semantic proximity Read ↗

Lack of an association between alleles of interleukin-1 alpha and interleukin-1 receptor antagonist genes and Graves' disease in a North American Caucasian population.Semantic proximity Read ↗

Allele 2 of interleukin-1 receptor antagonist gene increases the risk of thyroid peroxidase antibodies in subacute thyroiditis.Semantic proximity Read ↗

Influence of interleukin-1 receptor antagonist gene polymorphism on disease.Semantic proximity Read ↗

Interleukin-1 receptor antagonist gene polymorphism and rheumatoid arthritis.Semantic proximity Read ↗

Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist.Semantic proximity Read ↗

Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus.Semantic proximity Read ↗

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