Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene.

The Journal of clinical endocrinology and metabolism - 1 Jan 1995

Blakemore A I, Watson P F, Weetman A P, Duff G W

Abstract excerpt

The proinflammatory cytokine, interleukin-1 (IL-1), has been implicated in the pathogenesis of several autoimmune and inflammatory diseases. One of its natural inhibitors, IL-1 receptor antagonist, is a potent antiinflammatory agent. We have previously described genetic associations between an allele of the IL-1 receptor antagonist gene (IL1RN*2) and several autoimmune and inflammatory diseases. In the present...

Topics

Alleles
Antithyroid Agents
Cohort Studies
Eye Diseases
Female
Genes
Genotype
Graves Disease
Humans
Male
Receptors, Interleukin-1
Thyroiditis, Autoimmune

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 7530255
DOI: 10.1210/jcem.80.1.7530255

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7530255-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Graves' disease with an allele of the interleukin-1 receptor antagonist gene.PMID 7530255Read ↗

Lack of association of Graves' disease with the A2 allele of the interleukin-1 receptor antagonist gene in a white European population.Semantic proximity Read ↗

Graves' ophthalmopathy and gene polymorphisms in interleukin-1alpha, interleukin-1beta, interleukin-1 receptor and interleukin-1 receptor antagonist.Semantic proximity Read ↗

Interleukin-1-beta gene, but not the interleukin-1 receptor antagonist gene, is associated with Graves' disease.Semantic proximity Read ↗

Genetic Associations of Interleukin-related Genes with Graves' Ophthalmopathy: a Systematic Review and Meta-analysis.Semantic proximity Read ↗

Polymorphisms in IL-1beta and IL-1 receptor antagonist genes are associated with myasthenia gravis.Semantic proximity Read ↗

Genetic susceptibility to Graves' ophthalmopathy: The role of polymorphisms in anti-inflammatory cytokine genes.Semantic proximity Read ↗

Lack of an association between alleles of interleukin-1 alpha and interleukin-1 receptor antagonist genes and Graves' disease in a North American Caucasian population.Semantic proximity Read ↗

Allele 2 of interleukin-1 receptor antagonist gene increases the risk of thyroid peroxidase antibodies in subacute thyroiditis.Semantic proximity Read ↗

Influence of interleukin-1 receptor antagonist gene polymorphism on disease.Semantic proximity Read ↗

Interleukin-1 receptor antagonist gene polymorphism and rheumatoid arthritis.Semantic proximity Read ↗

Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist.Semantic proximity Read ↗

Interleukin-1 receptor antagonist allele (IL1RN*2) associated with nephropathy in diabetes mellitus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.