Article
Genetic susceptibility to Graves' ophthalmopathy: The role of polymorphisms in anti-inflammatory cytokine genes.
Ophthalmic genetics - 1 Dec 2010
Khalilzadeh Omid, Anvari Mehdi, Esteghamati Alireza, Momen-Heravi Fatemeh, Rashidi Armin, Amiri Hoda Mojazi, Tahvildari Maryam, Mahmoudi Mahdi, Amirzargar Aliakbar
Abstract excerpt
BACKGROUND: Various polymorphisms occur in cytokine genes involved in inflammatory processes in Graves' ophthalmopathy (GO). Anti-inflammatory cytokines such as transforming growth factor- β (TGF-β), interleukin-10 (IL-10) and interleukin-4 (IL-4) are among those believed to be involved in the disease process. In this study, we investigated the association between 8 polymorphisms within the mentioned cytokines...
Topics
- Adult
- Case-Control Studies
- Cytokines
- DNA Primers
- Female
- Genetic Predisposition to Disease
- Graves Ophthalmopathy
- Humans
- Interleukin-10
- Interleukin-4
- Male
- Polymerase Chain Reaction
- Polymorphism, Genetic