Article
Novel genetic association between ulcerative colitis and the anti-inflammatory cytokine interleukin-1 receptor antagonist.
Gastroenterology - 1 Mar 1994
Mansfield J C, Holden H, Tarlow J K, Di Giovine F S, McDowell T L, Wilson A G, Holdsworth C D, Duff G W
Abstract excerpt
BACKGROUND/AIMS: Ulcerative colitis and Crohn's disease have well-recognized familial tendencies, but the genetic basis of this clinical observation remains unknown. The cytokine interleukin-1 receptor antagonist is a potent anti-inflammatory protein that can prevent immune-mediated bowel inflamm...
Topics
- Adult
- Alleles
- Base Sequence
- Chromosome Mapping
- Colitis, Ulcerative
- Crohn Disease
- Cytokines
- Homozygote
- Humans
- Inflammation
- Molecular Probes
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Receptors, Interleukin-1