Article
Colorectal hyperplasia and inflammation in keratin 8-deficient FVB/N mice.
Genes & development - 15 Dec 1994
Baribault H, Penner J, Iozzo R V, Wilson-Heiner M
Abstract excerpt
We report that keratin 8 (mK8) gene disruption causes colorectal hyperplasia in FVB/N mice. The intestinal lesions affect uniformly the cecum, colon, and rectum but not the small intestine. The elongation of the crypts is accompanied by an inflammation of the lamina propria and submucosa. Hepatic...
Topics
- Aging
- Animals
- Base Sequence
- Cecum
- Colon
- Crosses, Genetic
- DNA Primers
- Female
- Fertility
- Genotype
- Homozygote
- Hyperplasia
- Infertility, Female
- Keratins
- Litter Size
- Male
- Mice
- Mice, Inbred C57BL